In the present work fast dissolving tablets of Promethazine hydrochloride were prepared by direct compression with a view to enhance patient compliance. Three different superdisintegrants crosscarmellose, tulsion 414 and crospovidone in three different concentrations (2%, 3% and 5%) and nine formulations were made. The granules were examined for pre-compression parameters. The prepared formulations were evaluated for weight variation, friability and hardness, disintegration time, wetting time, % drug content and in vitro drug release. All the formulations showed low weight variation with disintegration time of less than 60 seconds. Tablets containing 3%, 5% crospovidone showed excellent in vitro dispersion time and in vitro drug release as compared to other formulations.
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